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. 2021 May 17;11:9668. doi: 10.1038/s41598-021-88414-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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¹⁸F-FDG accumulation in hypoxic tumor cells expressing human S100A4. (a) Magnified view of micro-autoradiographic image showing the pimonidazole-positive and S100A4-negative area, and (b) the pimonidazole-positive and S100A4-positive area. (c) Determination of grain density in pimonidazole-positive and S100A4- negative or positive area focusing on ROIs of the same size (n = 3, mean ± SEM, Student t-test, one-sided, *: p < 0.05). Pim: Pimonidazole. Bars: 100 μm (S100A4, Pimonidazole, Hoechst, Merge and Silver grains), 10 μm (a,b).