Table 2.
(A) Multivariate analysis including variables with a p-value <0.10 identified in the univariate analysis, (B) Second multivariate analysis in which the presence of any positive aPL was separated into classic aPL, IgG/IgM aPS/PT, and IgA aB2GPI positivity, (C) Multivariate analysis including only the significant variables described in the second model.
| A) 1st Multivariate analysis | |||||
|---|---|---|---|---|---|
| Variable | Univariate | Multivariate | |||
| Odds ratio | 95% CI | Odds ratio | 95% CI | p-value | |
| Age (years) | 1.03 | 1.02–1.05 | 1.01 | 0.99–1.03 | 0.213 |
| Any positive aPL | 2.63 | 1.45–4.76 | 2.28 | 1.09–4.78 | 0.028 |
| Dyslipidemia | 2.26 | 1.44–3.55 | 1.69 | 1.01–2.83 | 0.046 |
| Diabetes mellitus | 2.65 | 1.48–4.73 | 1.60 | 0.84–3.06 | 0.151 |
| Arterial hypertension | 2.84 | 1.81–4.47 | 1.82 | 1.03–3.19 | 0.038 |
| Atrial fibrillation | 5.76 | 2.67–12.43 | 4.40 | 1.95–9.90 | <0.001 |
| Active smoker | 1.86 | 0.98–3.53 | 3.45 | 1.71–6.93 | 0.001 |
| AUC 0.756 | 0.71–0.80 | ||||
| B) 2nd Multivariate analysis | |||||
| Variable | Univariate | Multivariate | |||
| Odds ratio | 95% CI | Odds ratio | 95% CI | p-value | |
| Age (years) | 1.03 | 1.02–1.05 | 1.01 | 0.99–1.03 | 0.218 |
| Positive classic aPL | 2.56 | 0.72–9.03 | 2.03 | 0.53–7.85 | 0.304 |
| Positive IgA B2GPI | 3.53 | 1.61–7.72 | 2.40 | 1.03–5.53 | 0.042 |
| Positive IgG/IgM aPSPT | 1.95 | 0.71–5.36 | 1.14 | 0.34–3.80 | 0.835 |
| Dyslipidemia | 2.26 | 1.44–3.55 | 1.70 | 1.01–2.84 | 0.045 |
| Diabetes mellitus | 2.65 | 1.48–4.73 | 1.59 | 0.83–3.05 | 0.161 |
| Arterial hypertension | 2.84 | 1.81–4.47 | 1.82 | 1.03–3.22 | 0.041 |
| Atrial fibrillation | 5.76 | 2.67–12.43 | 4.31 | 1.90–9.78 | <0.001 |
| Active smoker | 1.86 | 0.98–3.53 | 3.47 | 1.72–6.99 | <0.001 |
| AUC 0.758 | 0.71–0.80 | ||||
| C) Analysis of significant variables in second model | |||||
| Variable | Odds ratio | 95% CI | Coefficient | Std. Error | Wald |
| Positive IgA aB2GPI | 2,60 | 1,13 to 5,94 | 0,954 | 0,422 | 5,106 |
| Dyslipidemia | 1,90 | 1,15 to 3,11 | 0,639 | 0,253 | 6,380 |
| Arterial hypertension | 2,26 | 1,36 to 3,75 | 0,814 | 0,259 | 9,877 |
| Atrial fibrillation | 5,01 | 2,26 to 11,10 | 1,611 | 0,406 | 15,724 |
| Active smoker | 3,23 | 1,63 to 6,41 | 1,172 | 0,35 | 11,207 |
| Raw constant | −0,625 | 0,222 | 7,905 | ||
| Adjusted* constant | −4.810 | 0,222 | 7,905 | ||
aB2GPI, anti-β2-glycoprotein-I antibodies; aCL, anti-cardiolipin antibodies; aPL, antiphospholipid antibodies; aPS/PT, anti-phosphatidylserine/prothrombin antibodies; AUC, area under the ROC curve.
*
Adjusted to prevalence in general population. Significant values are written in bold.