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. 2021 May 3;8:617393. doi: 10.3389/fmed.2021.617393

Figure 2.

Figure 2

Tanshinone IIA (TIIA)+ cyclosporine A (CsA) preserved lung architecture in renal ischemia-reperfusion (IR)-induced lung injury. Rats were pretreated with TIIA alone or in combination with CsA followed by removing the right kidney and clamping of the left renal artery for 30 min and reperfusion for 24 h. Sham rats were used as control. Representative photomicrographs of lung histology (A), the scale bars represent a length of 200 μm on histology, and lung injury scores (B) were evaluated under different conditions. The scale bars represent a length of 200 μm on histology. Electron microscope pictures (×40,000) of rat lung tissue after renal ischemia-reperfusion (IR). Abnormal mitochondrial (paired black arrow) morphology showed mitochondrial membrane rupture or swellings; normal mitochondrial (single black arrow) morphology type showed smooth mitochondrial membrane and smooth and distinct inner carinulae (C), and percentage of damaged mitochondria (D). Data are shown as mean ± SD. *p < 0.05 vs. sham group, #p < 0.05 vs. IR (obese) group, Δp < 0.05 vs. TIIA group, ▴p < 0.05 vs. CsA group.