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. 2021 May 3;8:617393. doi: 10.3389/fmed.2021.617393

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Copyright © 2021 Tai, Jiang, Song, Xiao, Li, Cheng, Yin, Chen, Yang, Jiang, Kuang, Lan and Jia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Tanshinone IIA (TIIA)+ cyclosporine A (CsA) inhibited lung cells apoptosis after renal ischemia-reperfusion (IR). (A) Lung apoptosis with TUNEL; (B) TUNEL-positive cells in lung; (C) caspase-3 activity. Rats were pretreated with TIIA alone or in combination with CsA followed by removing the right kidney and clamping of the left renal artery for 30 min and reperfusion for 24 h. Sham rats were used as control. Representative apoptosis of lung cells (A) and TUNEL-positive cells (B) were evaluated under different conditions. The scale bars represent a length of 100 μm on histology. The activity of myocardial caspase-3 (C), the protein expression of cleaved caspase-3 (D), and the protein expression of cleaved caspase-3 (E) were evaluated in different groups. Data are shown as mean ± SD. *p < 0.05 vs. sham group, ^#p < 0.05 vs. IR (obese) group, ^Δp < 0.05 vs. TIIA group, ^▴p < 0.05 vs. CsA group.