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. 2021 May 3;8:617393. doi: 10.3389/fmed.2021.617393

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Copyright © 2021 Tai, Jiang, Song, Xiao, Li, Cheng, Yin, Chen, Yang, Jiang, Kuang, Lan and Jia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Tanshinone IIA (TIIA)+ cyclosporine A (CsA) preserved lung mitochondrial function in renal ischemia-reperfusion (IR)-induced lung injury. The MMP (ratio of red/green), the mitochondrial ATP, the opening of mPAP (%), the mitochondrial ROS, the mitochondrial RCR, and the mtDNA damage (ratio of long/short fragments) were recorded above. Rats were pretreated with TIIA alone or in combination with CsA followed by removing the right kidney and clamping of the left renal artery for 30 min and reperfusion for 24 h. Sham rats were used as control. *p < 0.05 vs. sham group, ^#p < 0.05 vs. IR (obese) group, ^Δp < 0.05 vs. TIIA group, ^▴p < 0.05 vs. CsA group.