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. 2021 May 3;8:668107. doi: 10.3389/fmed.2021.668107

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Copyright © 2021 Lai, Hsieh, Lin, Wang, Lin, Hsia, Bair, Chen, Chiu and Weng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Illustrated the treat and extend (T&E) dosing algorithm in our real world study to determine treatment intervals. In this study, there were 3 monthly injections of ranibizumab, and injection intervals were extended by 4 weeks if there was no DME recurrence. DME recurrence was defined as having central retinal thickness >300 μm. If there was no recurrence, patients were allowed to extend their clinical visit and injection one more month due to personal reasons. BCVA, best-corrected visual acuity; DME, diabetic macular edema.