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. Author manuscript; available in PMC: 2021 Jul 21.
Published in final edited form as: Prog Retin Eye Res. 2020 Nov 17;83:100917. doi: 10.1016/j.preteyeres.2020.100917

Fig. 12. Schlemm’s canal inlet valve attachments to SC external wall at collector channel entrances.

Fig. 12.

Scanning electron microscopy images (A, B) are from an eye with an IOP of 4 mm Hg during fixation. An SC inlet valve has a funnel shaped (FNL) region as it joins the trabecular meshwork (TM). The funnel region leads to a cylindrical area that crosses SC to attach at collector channel entrances (CCE). The section in (A) bisects the SC inlet valve lumen of the conduit-like pathway (CLP), revealing the lumen connection between the funnel-shaped juxtaeanalieular space and collector channel entrance. Internal structural features are like those of the juxtaeanalieular space. (B) A view of the funnel region of a Schlemm’s inlet valve with a plane of section revealing its surface features as it courses across the canal from the TM to SC external wall at the entrance of a collector channel. (C) Viscoelastic dilated Schlemm’s canal (SC) before fixation. The image reveals the conduit-like pathway (CLP) of the Schlemm’s canal inlet valve as it arises from the TM and attaches to a hinged collagen flap (HCF) at SC external wall. The inlet valve is bisected, revealing an open distal end in communication with a collector channel entrance (CCE). Aqueous can flow freely into SC and CCE through the lumen of the conduit-like pathways. Tissue source: Primate, Macaca nemestrina. From the Johnstone Glaucoma Lab, University of Washington.