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. 2021 May 3;12:671073. doi: 10.3389/fimmu.2021.671073

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Copyright © 2021 Maretti-Mira, Golden-Mason, Salomon, Kaplan and Rosen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transcriptome-based signature and biological processes triggered by HoxLDL stimulation. (A) Using the top 40 genes upregulated HoxLDL biomarker list, we performed a network test using GeneMANIA, which identified a strong relationship among the 25 genes. (B) In the heatmap, we can see that the hierarchical clustering of the 25 genes (HoxLDL group), group all the HoxLDL-stimulated samples together (n=5). (C) Biological processes upregulated in M2-like cells exposed to MoxLDL and HoxLDL for 24 hours.