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. 2021 May 3;12:634847. doi: 10.3389/fimmu.2021.634847

Figure 1.

Figure 1

The frequency of circulating regulatory T cells (Tregs) was increased in idiopathic orbital inflammation (IOI). The frequencies of Tregs in patients with IOI and healthy control subjects were evaluated by flow cytometry. (A, B) The frequencies and absolute number of circulating Tregs and conventional T cells (Tconvs) in healthy controls (n=30) and patients with IOI (n=36). (C) Frequencies of circulating Tregs compared between patients stratified by IgG4-related disease (IgG4-RD), disease activity, allergic history and glucocorticoid therapy history status. (D) Compare the serum IgG4 between IOI patients with and without a history of glucocorticoids. (E) Association between circulating Tregs and serum IgG4 levels in patients with IOI. *P < 0.05; **P < 0.01; ****P < 0.0001; ns, not significant.