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. 2021 May 3;9:653207. doi: 10.3389/fcell.2021.653207

FIGURE 5.

FIGURE 5

Circ_0021205 suppresses CCA cell proliferation, migration and invasion through miR-204-5p/RAB22A axis. (A,B) Western blot results showed that circ_0021205 regulated RAB22A expression through sponging miR-204-5p. (C,D) The proliferation ability of treated HuCCT1 and KMBC cells were detected by CCK-8 assay and colony formation assay. (E) Transwell assay was performed to detect the migration and invasion of treated HuCCT1 and KMBC cells. All experiments were repeated at least three time. **P < 0.01. # and ## mean the significant differences between oe-circ_0021205+miR-mimics and oe-circ_0021205+NC-mimics orsi-circ_0021205+miR-inhibitors and si-circ_0021205+NC-inhibitors.