Table 1.

Factors determining disease risk in AML.

Clinical Variables	Molecular variables	Dynamic variables
• Age	• Cytogenetic	• Response to course 1 by morphology
• Gender	• Next generation sequencing of genes e.g. FLT3, NPM1, RUNX1, ASXL1, TP53	• Response to treatment by MRD
• Presenting white cell count
• Primary versus secondary disease
• Performance status