Table 2.
Principal pathways of Proliferation, differentiation and metabolism Cluster for the subset A.
| Proliferation, differentiation and metabolism | Upregulated genes | Downregulated genes |
|---|---|---|
| Mesodermal Commitment Pathway | KLF5, ASCC3, HNF4A, HPRT1, HMGA2 | ATP8B2, PBX1, ARID5B |
| Plasma lipoprotein assembly, remodeling, and clearance | APOC2, APOE, APOC1, NCEH1 | VLDLR |
| Adipogenesis | KLF5, TRIB3, LMNA | CNTFR |
| Cholesterol metabolism (includes both Bloch and Kandutsch-Russell pathways) | FASN | TM7SF2, CYP27A1 |
| DNA Replication | CDC7, POLA2, POLE2 | |
| G1 to S cell cycle control | POLE2, CREB3L1, POLA2 | |
| Genotoxicity pathway | HIST1H2BI, HIST1H2BM, HIST1H3D | |
| Trans-sulfuration pathway | GCLM, DNMT1 | GGT6 |
| Oxidative Stress | HMOX1, NOX4 | MT1X |
| Fatty Acid Biosynthesis | FASN | ECHDC2, ACACB |
| Apoptosis-related network due to altered Notch3 | APOE | TRAF1, NGFRAP1 |
| Ectoderm Differentiation | STC1 | CCL2, CTNND2 |
| G1 to S cell cycle control | POLE2, CREB3L1, POLA2 | |
| Genotoxicity pathway | HIST1H2BI, HIST1H2BM, HIST1H3D | |
| Trans-sulfuration pathway | GCLM, DNMT1 | GGT6 |
| Oxidative Stress | HMOX1, NOX4 | MT1X |