Table 4.
Principal pathways of Signaling Cluster for the subset B.
| Signaling | Upregulated genes | Downregulated genes |
|---|---|---|
| Focal Adhesion-PI3K-Akt-mTOR-signaling pathway | CSF3, COL4A2, FN1, OSMR, ITGA3, LAMA5, CSF3R, EFNA2, PDGFB, PGF, FGFR4, SLC2A1, PFKFB3, PFKFB4 | PRLR, AKT3, FGF10, FGF7 |
| Nuclear Receptors Meta-Pathway | CYP2B6, BHLHE40, SLC2A1, GPR115, PTGS2, ANGPTL4, PDGFB, FGFBP1, SLC6A8, SLC39A4, SLC39A5, SCD | NR0B2, ALDH3A1, SOD3, SNAI2, ADH7, PLTP |
| PI3K-Akt Signaling Pathway | CSF3, COL4A2, FN1, OSMR, ITGA3, LAMA5, CSF3R, EFNA2, PDGFB, PGF, FGFR4 | PRLR, AKT3, FGF10, FGF7, FLT3LG, COL9A2 |
| MAPK Signaling Pathway | PDGFB, IL1R2, FGFR4, HSPA6, HSPA1B | AKT3, PRKACB, MRAS, CACNA2D3, FGF7, FGF10 |
| VEGFA–VEGFR2 Signaling Pathway | NCF2, TNFRSF10C, GJA1, PTGS2, SELE, SOD2, PGF | PRKCB, PRKD1, TXNIP |
| GPCRs, Class A Rhodopsin-like | FPR1, CCRL2, ADORA2B | HTR2A, CCBP2, OR2W1, PTGER1, PTGFR |
| NRF2 pathway | SLC2A1, PDGFB, SLC6A8, SLC39A4, SLC39A5 | SOD3, ADH7, ALDH3A1 |
| Vitamin D Receptor Pathway | TREM1, CYP2B6, S100A9, S100A8, SALL4, CYP2D6 | BGLAP, IGFBP5 |
| Ras Signaling | FGFR4 | PRKACB, MRAS, PAK3, AKT3, PLA2G1B, PRKCB |
| Regulatory circuits of the STAT3 signaling pathway | SOCS3, OSMR, CSF3R | PTPRC, PRKCB, DEPTOR |
| PPAR signaling pathway | SCD, ANGPTL4, FADS2, OLR1 | HMGCS2, PLTP |
| Glucocorticoid Receptor Pathway | BHLHE40, FGFBP1, PTGS2, GPR115, ANGPTL4 | SNAI2 |
| Gastrin Signaling Pathway | SERPINE1, MMP7, PTGS2 | ARHGEF28, PRKD1 |
| Wnt Signaling | PRKCB, ROR1, SERPINF1, SFRP2, SFRP5 | |
| Nuclear Receptors | NR5A2 | THRB, ROR1, NR2F1, NR2F2 |
| EGF/EGFR Signaling Pathway | GJA1, E2F1 | VAV3, PRKCB |
| JAK/STAT | SOCS3, SIRPA, TIMP1 | PRLR |
| Brain-Derived Neurotrophic Factor (BDNF) signaling pathway | SIRPA, NCF2 | VAV3, KCNA3 |
| ErbB Signaling Pathway | AKT3, PRKCB, PAK3 | |
| Insulin Signaling | SLC2A1, SOCS3 | RPS6KA6 |
| G Protein Signaling Pathways | PRKD1, PRKACB, AKAP12 |