TABLE 1.

Detailed information on plant-derived miRNAs with cross-kingdom activity in mammals.

No	Name of miRNA	Original plant	MiRNA sequence	MiRNA Target	References
1	miR168a	Rice	UCGCUUGGUGCAGAUCGGGAC	Human/mouse low-density lipoprotein receptor adapter protein 1	Zhang et al., 2012
2	miR2911	Honeysuckle	AGGGUCGGGCAGGGGGCCGG	The PB2 or NS1 gene of viral genome of influenza A virus (H1N1, H5N1, H7N9)	Zhou et al., 2015
3	miR2911	Honeysuckle	AGGGUCGGGCAGGGGGCCGG	The viral genome of the novel Coronavirus SARS -CoV-2	Zhou et al., 2020
4	miR471	Lettuce	UCCCAUAGGAAUCUUGUGAAA	Hepatitis B virus (HBV)	Zhang et al., 2019
5	miR519	Lettuce	ACAAAUGGCACUAGUAAACUG	Hepatitis B virus (HBV)	Zhang et al., 2019
6	miR159	Glycine max Arabidopsis thaliana	UUUGGAUUGAAGGGAGCUC	Transcription factor 7 of breast cancer cell	Chin et al., 2016
7	gma-miR159a-3p	Soybean	UUUGGAUUGAAGGGAGCUCUA	Transcription factor 7 of human colonic Caco-2 cancer cell	Liu et al., 2020
8	MiR171 variant	Arabidopsis, tomato, etc.	UGAUUGAGCCGCGCCAAUAUC	mTOR pathway of HEK293 cell	Gismondi et al., 2021
9	FvmiR168	Strawberry fruits	UCGCUUGGUGCAGGUCGGGAA	Toll-Like Receptor 3 of T cell and mouse	Cavalieri et al., 2016
10	miR-396	Astragalus	UUCCACAGCUUUCUUGAACUU	Endothelial transcription factor 3 of Th2 cells in mouse	Shen et al., 2019; Abla et al., 2019
11	Gas-miR01	Gastrodia elata	UUCAAUAAAGCUGUGGGAAA	A20 gene of 293T cell and mouse	Zhou, 2018
12	Gas-miR02	Gastrodia elata	GUUCAGGAAUGCUGUGGGAAG	A20 gene of 293T cell and mouse	Zhou, 2018; Xia et al., 2020
13	miR156a	Cabbage, Spinach and Lettuce	UGACAGAAGAGAGUGAGCAC	Junctional adhesion molecule A of human endothelial cell	Hou et al., 2018
14	aba miRNA 9497	Atropa belladonna	UUUCUGAAUCCAUUGUUUAUC	zinc-finger transcription factor ZNF-691 of HNG cells	Avsar et al., 2020
15	miR5338	Rape bee pollen	UGAAGCUUCAGUUGGUUGUAU	Mitochondrial fusion requires fusion protein 1 in rat	Chen et al., 2018; Peng et al., 2011
16	miR167e-5p	Moringa Oleifera and Maize	UGAAGCUGCCAGCAUGAUCUG	β-catenin of IPEC-J2 and Caco-2 cell	Li et al., 2019a
17	miR156	Soybean, Wheat and Maize	UGACAGAAGAGAGUGAGCAC	Wnt10b in mouse	Li et al., 2019b
18	mdo-miR7267-3p	Ginger	CAUCCAGCCAUCCACCCCAGG CCAUC	LGG monooxygenase ycnE of mouse gut microbiota	Teng et al., 2018