Table 3.

Advantages of anti-EGFR antibodies in head and neck cancer.

Advantages of anti-EGFR antibodies in head and neck cancer

1. Have been shown by us to detect very small ($<8\mathrm{mg}$) pieces of tumor

2. Accumulate rapidly inside the tumor since receptor expression and turnover is higher in tumors than normal tissues (the antibody that binds to EGFR is internalized, and then the receptor recycles to the surface).26

3. Are simple to manufacture, highly specific for cancer, and shown to be safe.27,28

4. Can be labeled and successfully target tumors for optical and nuclear imaging.