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Mitochondria arrived into hepatocyte through macropinocytosis pathway. (a) Isolated mitochondria. Mitochondria were stained by Mitotracker CMXRos, a mitochondrial specific dye. The dye conjugates thiols of mitochondrial proteins with covalent bonding. (b) Mitochondria morphology under TEM. (c) Cell internalization of mitochondria was prevented by macropinocytosis inhibitor. The cells were respectively added 8 × 104 mitochondria, and then were observed under TEM at 4 h after addition
