Fig. 2.

COVID-19 disease module. (A) Proteins targeted by SARS-CoV-2 are not distributed randomly in the human interactome, but form a large connected component (LCC) consisting of 208 proteins, and multiple small subgraphs, shown in the figure. Almost all proteins in SARS-CoV-2 LCC are also expressed in the lung tissue, potentially explaining the effectiveness of the virus in causing pulmonary manifestations of the disease. (B) The random expectation of the LCC size indicates that the observed COVID-19 LCC, whose size is indicated by the red arrow, is larger than expected by chance (z-score = 1.65). (C) Heatmap of the Kendall τ statistic showing that the ranking list predicted by the different methods (A, D, and P) are not correlated. We observe, however, high correlations among the individual ranking list predicted by the same predictive method.