Anti-HCV properties of tetracyclic indole derivatives.
Compd | Anti-HCV activity (EC50, nM) | |||||||
---|---|---|---|---|---|---|---|---|
Genotypes | ||||||||
1a | 1b | 2a | 2b | 3a | 4a | 1a Y93H | 1a L31V | |
4 | 0.003 | 0.003 | 0.007 | 23 | 0.09 | 0.03 | 8 | 7 |
5 | 0.002 | 0.002 | 0.001 | 2 | 0.3 | 0.04 | 4 | 1 |
6 | 0.003 | 0.004 | 0.002 | 1 | 0.02 | 0.03 | 5 | 1 |
7 | 0.0008 | 0.0007 | 0.008 | 10 | 0.4 | 0.02 | 11 | 0.8 |