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. 2020 Nov 6;11(12):1335–1353. doi: 10.1039/d0md00288g

Anti-HCV properties of pyrimidoindole-ribonucleoside derivatives.

Compd Anti-HCV activity (gt 1b) Cytotoxicity SI
IC50, μM CC50, μM
22 1.6 22.9 14.3
23 3.1 >44.4 >14.3
24 2.5 >44.4 >17.8
25 3.0 >44.4 >14.8
26 2.3 >44.4 >19.3
Mericitabine 1.2 >44.4 >37