Anti-HCV properties of pyrimidoindole-ribonucleoside derivatives.
Compd | Anti-HCV activity (gt 1b) | Cytotoxicity | SI |
---|---|---|---|
IC50, μM | CC50, μM | ||
22 | 1.6 | 22.9 | 14.3 |
23 | 3.1 | >44.4 | >14.3 |
24 | 2.5 | >44.4 | >17.8 |
25 | 3.0 | >44.4 | >14.8 |
26 | 2.3 | >44.4 | >19.3 |
Mericitabine | 1.2 | >44.4 | >37 |