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Gene expression patterns in human NP cells
| MMPs mRNA | CollagenI/β‐actin | CollagenIi/β‐actin | Aggrecan/β‐actin | sGAG/DNA | Hyp/DNA | |
|---|---|---|---|---|---|---|
| rhGDF‐5 | ↓ | ↓ | ↑↑↑ | ↑↑ | ↑↑ | ↑↑↑ |
| Ad‐GDF‐5 | ↓ | ↓ | ↑↑↑ | ↑↑ | ↑↑ | ↑↑↑ |
sGAG: The total proteoglycan level. Hyp: The total collagen content. Red arrows indicate important material changes and the number of arrows is positively correlated with the degree of change.
