TABLE 4.
GDF‐5 inhibits relative mRNA level of inflammatory factors
NF‐κB signaling pathway | TNF‐α/mRNA | IL‐1β/m RNA | COX2/mRN A | iNOS/mRN A | collagen/β‐actin | Aggrecan/ β‐actin | |
---|---|---|---|---|---|---|---|
rhGDF‐5 | ↓ | ↓ | ↓ | ↓ | ↓ | ↑ | ↑ |
Ad‐GDF‐ 5 | ↓ | ↓ | ↓ | ↓ | ↓ | ↑ | ↑ |
The arrow indicates the change trend of the substance.