Trypanocidal activity (EC50), cytotoxicity (CC50) and selectivity index (SI) for the set of compounds using the amastigote form of two strains (Y and Tulahuen) of T. cruzi in the mammalian host cells (U2OS and LLC-MK2).
| Neq ID | EC50 Tc Y (μM) | CC50 U2OS (μM) | SI | EC50 Tc Tula (μM) | CC50 LLC-MK2 (μM) | SI |
|---|---|---|---|---|---|---|
| 409 a | — | — | — | Inact | >100 | ND |
| 500 | 3.6 | >100 | >27.8 | Inact | >100 | 1.1 |
| 539 | 5.1 | >100 | >19.6 | 25.8 | >100 | >3.9 |
| 570 a | — | — | — | Inact | >100 | ND |
| 615 | ND | ND | ND | Inact | >100 | ND |
| 646 | 6.0 | >100 | >16.6 | ND | ND | ND |
| 652 | ND | ND | ND | Inact | >100 | ND |
| 653 | ND | ND | ND | Inact | >100 | ND |
| 654 | ND | ND | ND | 79.6 | >100 | >1.2 |
| 655 | 1.0 | 6.0 | 4.4 | Inact | >100 | ND |
| 656 | 0.1 | 3.0 | 58.4 | Inact | >100 | ND |
| 657 | 12.1 | >100 | >8.2 | ND | ND | ND |
| 673 | 22.4 | >100 | >8.2 | ND | ND | ND |
| 675 | Inact | >100 | ND | ND | ND | ND |
| 677 | 3.2 | 10.2 | 3.2 | 21.7 | 42.0 | 1.9 |
| 690 | 8.4 | 26.9 | 3.2 | 8.4 | 26.9 | 3.2 |
| Bz | 5.1 | >100 | >19.6 | 4.3 | >100 | >23.3 |
a
Values retrieved from the recent literature.7