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. 2021 May 3;12:636457. doi: 10.3389/fphar.2021.636457

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Copyright © 2021 Yang, Cai, Chen, Gang, Wei, Zhu, Li, Yang, Luo, Bi and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of THCQ on collagenase-induced ICH. SD rats were challenged by right striatum injection of 4 μg collagenase. Brain tissues were collected 72 h after challenge with collagenase. Typical macrographs (left: sham, 72 h after operation; right: 72 h after ICH induction) (A). Normal cerebral striatum (b, B) and striatum 72 h after collagenase injection, showing infiltration of inflammatory cells (c, C), ICH + THCQ-L (28.2 mg·kg⁻¹) (d, D), ICH + THCQ-M (56.4 mg·kg⁻¹) (e, E) and ICH + THCQ-H (112.7 mg·kg⁻¹) (f, F). The histological morphology and pathology results showed that treatment with THCQ alleviated ICH-induced pathological changes.