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. 2021 May 3;9:660145. doi: 10.3389/fbioe.2021.660145

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Copyright © 2021 Sivaraj, Chen, Chattopadhyay, Henn, Wu, Noishiki, Magbual, Mittal, Mermin-Bunnell, Bonham, Trotsyuk, Barrera, Padmanabhan, Januszyk and Gurtner.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sources of stem cells to be used as cellular therapies. (A) Adipose-derived stem cells (ASCs) can be harvested from either lipoaspirate or fat tissue. These cells (or MSCs) can then be cultured in vitro, expanded in number, and then delivered to the wound as a cell therapy. To enhance the cell delivery, several delivery techniques (shown later) may be used. (B) Mesenchymal stromal cells (MSCs) can be harvested from either the umbilical cord or the bone marrow.