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. 2021 May 3;11:642527. doi: 10.3389/fonc.2021.642527

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Copyright © 2021 Li, Feng, Sun and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The relationship of five-gene risk groups with functional annotations, TME landscape, immune cell fractions, tumor mutation burden, PDL1 expression and chemotherapy response. (A) The Hallmark enrichment of high- and low-risk groups by GSEA method. (B) Landscape of immune and stromal microenvironment based on immune and stromal signature. (C) Boxplot of the distribution of 22 immune cells in the high- and low-risk groups. (D) PDL1 expression differences. (E) Tumor mutation burden difference. (F) Estimated IC50 indicates the efficiency of chemotherapy to high- and low-risk groups by Methotrexate.