Table 2. Biochemical Measurements 12 Months After Randomization by Tertile of Plasma EPA Level.
| Variable | Median (IQR) | |||||
|---|---|---|---|---|---|---|
| All patients (n = 10 382) | Corn oil (n = 5207) | All EPA (n = 5175) | Plasma EPA | |||
| Tertile 1 (n = 1733) | Tertile 2 (n = 1727) | Tertile 3 (n = 1715) | ||||
| Laboratory data | ||||||
| Cholesterol, mg/dL | ||||||
| Total | 158 (134-189) | 162 (138-192) | 154 (131-185) | 158 (131-197) | 144 (125-170) | 161 (141-192) |
| LDL | 76 (56-101) | 75 (55-100) | 76 (57-103) | 76 (56-110) | 71 (52-91) | 82 (63-107) |
| HDL | 37 (32-43) | 37 (32-42) | 37 (32-43) | 37 (32-43) | 37 (32-42) | 38 (33-43) |
| Triglyceride, mg/dL | 212 (159-288) | 235 (178-315) | 191 (145-255) | 198 (146-270) | 177 (139-228) | 198 (153-271) |
| Non-HDL cholesterol, mg/dL | 120 (97-150) | 124 (101-152) | 116 (94-146) | 119 (94-156) | 107 (88-132) | 123 (102-153) |
| Apolipoprotein B, mg/dL | 56 (44-70) | 56 (45-70) | 55 (44-70) | 56 (44-71) | 52 (42-66) | 57 (47-74) |
| Apolipoprotein C-III, mg/dL | 17 (13-21) | 18 (14-23) | 16 (13-20) | 16 (12-20) | 15 (12-19) | 17 (13-21) |
| hs-CRP, mg/dLa | 0.18 (0.09-0.38) | 0.18 (0.09-0.40) | 0.17 (0.08-0.37) | 0.18 (0.09-0.40) | 0.18 (0.09-0.38) | 0.15 (0.08-0.32) |
| Plasma EPA, ug/mL | 35 (16-92) | 19 (12-31) | 89 (46-131) | 30 (17-47) | 90 (76-103) | 151 (132-181) |
| RBC EPA, % of total | 1.0 (0.5-2.8) | 0.6 (0.4-0.9) | 2.8 (1.5-4.0) | 1.0 (0.6-1.7) | 2.9 (2.4-3.6) | 4.3 (3.5-5.1) |
| Plasma DHA, ug/mL | 75 (53-101) | 58 (44-80) | 91 (71-114) | 67 (53-84) | 88 (76-103) | 118 (102-143) |
| RBC DHA, % of total | 5.8 (4.5-6.8) | 4.8 (3.8-6.0) | 6.6 (5.7-7.3) | 5.7 (4.7-6.5) | 6.6 (6.1-7.3) | 7.1 (6.4-7.8) |
Abbreviations: DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; HDL, high-density lipoprotein cholesterol; hs-CRP, high-sensitivity C-reactive protein; IQR, interquartile range; LDL, low-density lipoprotein cholesterol; RBC, red blood cell.
SI conversion factor: To convert apolipoprotein to grams per liter, multiply by 0.01; cholesterol levels to millimoles per liter, multiply by 0.0259; hs-CRP to milligrams per liter, multiply by 10; triglycerides to millimoles per liter, multiply by 0.0113.
a
All follow-up measures were at 12 months, except for hs-CRP, which was measured at 60 months (n = 1390 in corn oil placebo and n = 1372 in ω-3 CA).