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Comparison of PU6 when bound to HTLV-1 and HIV-1 protease. (a) The phosphonate moiety of PU6 sticks out into the S1 subsite in HTLV-1, whereas it binds up against the flaps in HIV-1 protease. (b) Residue L57 prevents the phosphonate from interacting with the flaps of HTLV-1 protease.
