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. Author manuscript; available in PMC: 2022 Mar 24.
Published in final edited form as: Chem Rev. 2021 Jan 7;121(6):3238–3270. doi: 10.1021/acs.chemrev.0c00648

Figure 1.

Figure 1.

Traditional drug design and development process can result in clinical resistance, which renders therapies obsolete. Incorporating strategies to avoid resistance in the lead optimization of drug design can minimize the probability of resistance.