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Active site of the Simian immunodeficiency virus (from red-capped mangabeys) intasome in complex with bictegravir (BIC) and dolutegravir (DTG); protein, DNA, and drug are shown as sticks. Yellow spheres represent Mg2+ ions, and water molecules are shown as small red spheres. (A) Superposition of BIC (green) (PDB-ID: 6RWM) and DTG (pink) (PDB-ID: 6RWN) bound structures with protein and DNA shown in orange. (B) Q148H/G140S variant bound to BIC (PDB-ID: 6RWO).127
