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. Author manuscript; available in PMC: 2022 Mar 24.
Published in final edited form as: Chem Rev. 2021 Jan 7;121(6):3238–3270. doi: 10.1021/acs.chemrev.0c00648

Figure 9.

Figure 9.

Crystal structures of inhibitor-bound viral proteases, and the substrate envelopes determined through substrate-bound cocrystal structures. a) HIV-1 protease bound to darunavir (DRV; magenta sticks). The two protein chains that comprise the homodimeric protease are in light violet and gold cartoon representation, with DRV bound at the active site. b) HCV NS3/4A protease (light violet cartoon) with grazoprevir (GZR; magenta sticks) bound at the active site. c) HIV-1 protease substrate envelope (blue volume) and fit of DRV within the envelope. d) HCV NS3/4A protease substrate envelope (blue volume) and fit of GZR within the envelope.