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Molecular regulatory mechanism of LPS-induced inflammatory responses by TLR-4 and JAK2/STAT3 via IL-6 signaling. The anti-inflammatory activities of NTS are mediated by inhibiting these pathways and the binding of STAT3 to the promoter of the pro-inflammatory cytokine IL-6. LPS, lipopolysaccharide; NTS, non-toxic sulfur; TLR-4, Toll-like receptor 4; JAK2, Janus kinase 2; p-, phosphorylated; GAS, γ-interferon activation site.
