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. 2019 Feb 19;101(3):526–537. doi: 10.1093/biolre/ioz030

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© The Author(s) 2019. Published by Oxford University Press on behalf of Society for the Study of Reproduction.

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Figure 3. — Sex-dependent developmental programming of trophoblast elongation at day 15 of pregnancy by actions of CSF2 from day 5 to 7 of development. Panel A: Embryo length and accumulation of IFNT in uterine flushing. Panel B: Venn diagram illustrating relationship between differentially methylated probes of DNA isolated from trophoblast. Note that a large proportion of probes regulated by CSF2 in either females or males are also differentially methylated between female and male embryos. The figure is reproduced from ref. 86.