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. 2021 May 6;24(1):498. doi: 10.3892/mmr.2021.12137

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Copyright: © Jiang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — miR signatures of hepatocyte-released and serum-derived EVs in mice fed HFD or CD. (A) miR-122-5p, (B) miR-129-5p, (C) miR-135a-1-3p and (D) miR-504-3p were verified using RT-qPCR in hepatocyte-released EVs. Expression levels of (E) miR-122-5p, (F) miR-129-5p, (G) miR-135a-1-3p and (H) miR-504-3p were detected in serum-derived EVs isolated from mice fed HFD or CD mice using RT-qPCR (n=5/group). Data are presented as the mean ± SD. *P<0.05, **P<0.01, ***P<0.001. RT-q, reverse transcription-quantitative; miR, microRNA; HFD, high-fat diet; CD, chow diet; EVs, extracellular vesicles.