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. Author manuscript; available in PMC: 2021 May 17.
Published in final edited form as: Vascul Pharmacol. 2015 Oct 17;74:60–72. doi: 10.1016/j.vph.2015.10.003

Fig. 9.

Fig. 9.

Comparative expression of Rac- and Cdc42-guanine exchange factors for the DOCK family and ELMOs (binding partners) in HMEC. A, Alignment of the DHR2 catalytic domain of DOCK2 and DOCK9. Residues of the DHR2 sequences shown with a black background correspond to those at the interacting interface within 3 Å of distance between the DHR2 domain and the GTPase of the complexes shown in B and C, in which the interacting amino acids are highlighted. D. Phylogenetic organization of the DOCK family of Rac- and Cdc42-GEFs based on the structure of their DHR2 domains (left panel). The central panel shows the predicted structure of the DOCK family, organized according to their phylogenetic relationships. Comparative expression of all members of the DOCK family is shown in the right panel. E. Comparative expression of ELMOs. The graphs in D and E show normalized relative expression of DOCKs and ELMOs respectively. Bars represent mean ± SEM of four independent experiments; ***p < 0.001, ****p < 0.0001.