Extended Data Fig. 6 |. Results testing for a modulating effect of sex.

Colour coded heatmap of β-estimates for a sex-metabolite interaction term in Cox proportional hazard models. Cox models were run with the metabolite, sex, and a sex-metabolite interaction term as exposure and disease onset as outcome with age as the underlying time scale. Red shades indicate a stronger effect among women, whereas blue indicates the opposite. Rectangles surrounded with a black frame indicate a p-value<0.001 correcting for 28 outcomes tested for each metabolite.