TABLE 2.
Overlaps between WMHs and FreeSurfer GM segmentations, and their associations with overal WMH burden. The regions are sorted based on effect size. Significant results after FDR correction are indicated in bold font
| Structure name | FreeSurfer label | Volume (mm3) | Overlap with WMH (mm3) | Percentage of overlap (%) | Association with WMH | |
|---|---|---|---|---|---|---|
| T stat | p value | |||||
| Caudate—right | 50 | 3,532.9 ± 596.2 | 217.2 ± 271.0 | 6.153 | 46.57 | <.0001 |
| Caudate—left | 11 | 3,395.9 ± 556.4 | 222.9 ± 283.9 | 6.565 | 46.02 | <.0001 |
| Cerebral cortex—left | 3 | 202,864 ± 25,017 | 73.8 ± 240.5 | 0.036 | 31.81 | <.0001 |
| Cerebral cortex—right | 42 | 203,763 ± 25,182 | 79.8 ± 218.8 | 0.039 | 30.03 | <.0001 |
| Putamen—right | 51 | 4,235.6 ± 644.1 | 21.9 ± 74.4 | 0.518 | 23.02 | <.0001 |
| Putamen—left | 12 | 4,194.8 ± 648.3 | 17.4 ± 56.1 | 0.416 | 21.20 | <.0001 |
| Thalamus—left | 10 | 6,598.1 ± 729.3 | 1.01 ± 5.72 | 0.015 | 12.25 | <.0001 |
| Thalamus—right | 49 | 6,499.9 ± 711.3 | 0.55 ± 4.07 | 0.008 | 8.76 | <.0001 |
| Pallidum—right | 52 | 1829.0 ± 256.6 | 0.85 ± 3.50 | 0.047 | 8.63 | <.0001 |
| Accumbens area—left | 26 | 405.1 ± 86.6 | 0.23 ± 1.96 | 0.057 | 7.80 | <.0001 |
| Pallidum—left | 13 | 1863.1 ± 255.1 | 0.45 ± 2.50 | 0.024 | 5.99 | <.0001 |
| Accumbens area—right | 58 | 452.7 ± 90.7 | 0.17 ± 0.88 | 0.038 | 4.80 | <.0001 |
| Hippocampus—right | 53 | 3,572.6 ± 600.3 | 0.22 ± 2.24 | 0.006 | 3.70 | .0002 |
| Ventral diencephalon—right | 60 | 3,754.9 ± 459.5 | 0.10 ± 1.78 | 0.003 | 1.98 | .05 |
| Amygdala—right | 54 | 1,469.7 ± 319.3 | 0.04 ± 0.88 | 0.003 | 1.59 | .11 |
| Amygdala—left | 18 | 1,275.3 ± 299.1 | 0.01 ± 0.23 | 0.0001 | 0.77 | .44 |
| Ventral diencephalon—left | 28 | 3,782.2 ± 473.9 | 0.06 ± 2.03 | 0.002 | 0.74 | .45 |
| Hippocampus—left | 17 | 3,476.3 ± 564.9 | 0.17 ± 4.77 | 0.005 | 0.35 | .72 |