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. 2021 May 12:1–16. doi: 10.1080/08830185.2021.1925267

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© 2021 Taylor & Francis Group, LLC

This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

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Figure 3. — Bubble plot analysis of the SARS-CoV-2 spike protein. The plot shows the probable B cell epitopes from the variable (S1 domain: aa13 to aa685) and stalk region (S2 domain: aa686 to aa1273) of the Spike protein. The corresponding Vaxijen score and the percentage of candidate vaccine probability shown in y and x axis, respectively. The size of each bubble signifies the respective surface accessibility. The B cell epitopes from the stalk S2 domain have less surface accessibility making it a poor vaccine candidate compared to the highly accessible B cell epitopes in the variable S1 domain and RBD.