Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 May 12:1–16. doi: 10.1080/08830185.2021.1925267

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 Taylor & Francis Group, LLC

This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

PMC Copyright notice

Figure 4. — Structure and design of hybrid or chimeric VLP for SARS-CoV-2 vaccination. (A) The trimeric assembly of SARS-COV-2 Spike protein and Influenza HA. Residues from stalk region represented in a cartoon format, differnt colors signifies three different chains. The residues from the variable region those are making H-bond with the stalk are labeled (representative from a single chain) whereas all the other residues shown as a ribbon diagramme. Upper figure showing the H-bond interaction profile for a single chain stalk region (pink) within the trimeric assembly. (B) Influnza Hemagglutinin (HA) and SARS-CoV-2 Spike contain head and stalk domain. Matrix protein 1 (M1), either with chimeric Spike (stalk from HA with head from Spike). (C) Schematic diagram showing cooperation between influenza induced memory T cells and development of spike specific immune response.