Fig. 3.

Insulin had effects on insulin receptor β and factors involved in PM. a. The protein expression level of insulin receptor β was measured by western blotting at different concentrations of insulin treatment, *p < 0.05, ***p < 0.001 vs.. the control group, #p < 0.05, vs.. the 0.1 µg/mL insulin group. The protein levels of (b) TIMP-1, (c) MMP2, (d) bFGF, and (e) IGF-1, involved in pathological myopia, were detected with ELISA assay in ARPE-19 cells treated with 1 µg/mL of insulin for 24 or 72 h. *p < 0.05, **p < 0.01, ***p < 0.001 vs.. the blank group