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. 2021 May 10:1–21. doi: 10.1080/07391102.2021.1924271

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Figure 1. — Crystallographic structures showing the mains proteases: (A) M^Cov1_Pro (PDB code 2BX4) from SARS-CoV and (B) M^Cov2_Pro (PDB code 6LU7) from SARS-CoV-2. Domains I, II, III, Linker and N-Finger are shown in cartoons coloured in green, magenta, orange, yellow and blue, respectively. The active pocket is highlighted for each structure and S1₁, S1₂, S2 and S4 loops are shown in blue, green, pink and yellow sticks. Cyan sticks represent the catalytic dyad (His41 and Cys145) in both cases and the region of the mutation Ala46/Ser46 is depicted by red stars. Gray sticks represent remaining residues around 5 Å from the catalytic dyad.