Table 3.

Effectiveness of a single oral dose of Credelio Plus against natural nematode infections in dogs presenting to European veterinary clinics

NNematode species	Samplea	Treatment groupb	Number of dogs	Egg count per gram faeces
				Geometric Mean (GM)	GM % reduction	Number of dogs with zero eggs (%)	Effectiveness P-valuec
All nematode species	Pre-treatment	Credelio Plus Afoxolaner + MO	278 117	13.2 11.2	– –	– –	– –
	Post-treatment	Credelio Plus Afoxolaner + MO	278 117	0.3 0.3	97.6 97.0	245 (88.2%) 99 (84.6%)	< 0.0001 (t524 = 24.33)  < 0.0001 (t524 = 14.65)
Toxocara canis	Pre-treatment	Credelio Plus Afoxolaner + MO	54 19	16.4 8.0	– –	– –	– –
	Post-treatment	Credelio Plus Afoxolaner + MO	54 19	0.5 0.4	97.2 95.3	48 (88.9%) 16 (84.2%)	< 0.0001 (t79.3 = 4.36)  < 0.0001 (t79.3 = 9.70)
Ancylostoma caninum	Pre-treatment	Credelio Plus Afoxolaner + MO	109 42	11.2 9.9	– –	– –	– –
	Post-treatment	Credelio Plus Afoxolaner + MO	109 42	0.2 0.5	98.1 95.3	100 (91.7%) 35 (83.3%)	< 0.0001 (t185 = 9.28)  < 0.0001 (t185 = 17.19)
Trichuris vulpis	Pre-treatment	Credelio Plus Afoxolaner + MO	176 80	9.8 9.7	– –	– –	– –
	Post-treatment	Credelio Plus Afoxolaner + MO	176 80	0.2 0.1	97.8 98.5	156 (88.6%) 73 (91.2%)	< 0.0001 (t340 = 12.79)  < 0.0001 (t340 = 18.57)

MO milbemycin oxime

^aPre-treatment sample collected once on Day 0; post-treatment sample collected on Day 8 (range 7–10)

^bSingle oral administration of Credelio Plus on Day 0 to provide a dose range of 0.75–1.56 mg/kg bodyweight MO and 20.0–41.5 mg/kg bodyweight lotilaner. Single oral dose of Nexgard Spectra on Day 0 to provide a dose range of 2.50–5.36 mg/kg bodyweight of afoxolaner and 0.50–1.07 mg/kg bodyweight of MO

^cEffectiveness P-value is the P-value for the within-treatment difference in least-square means