Table 4.

Summary of success rate following a single oral dose of Credelio Plus against natural nematode infections in dogs presenting to European veterinary clinics

Nematode species	Treatment groupa	Number of dogs	Success rateb		Difference in success rate
			Successful dogs	Success rate (%)	Estimate	95% Confidence intervalc
All nematode species	Credelio Plus Afoxolaner + MO	278 117	254 103	91.4 88.0	3.33 –	(− 3.41, 10.08) –
T. canis	Credelio Plus Afoxolaner + MO	54 19	48 16	88.9 84.2	4.68 –	(− 13.74, 23.09) –
A. caninum	Credelio Plus Afoxolaner + MO	109 42	103 38	94.5 90.5	4.02 –	(− 5.84, 13.88) –
T. vulpis	Credelio Plus Afoxolaner + MO	176 80	161 75	91.5 93.8	− 2.27 –	(− 8.99, 4.45) –

MO milbemycin oxime

^aSingle oral administration of Credelio Plus on Day 0 to provide a dose range of 0.75–1.56 mg/kg bodyweight MO and 20.0–41.5 mg/kg bodyweight lotilaner. Single oral dose of Nexgard Spectra on Day 0 to provide a dose range of 2.50–5.36 mg/kg bodyweight of afoxolaner and 0.50–1.07 mg/kg bodyweight of MO

^bSuccessfully treated dog is one for whom the individual percentage reduction in egg counts at Day 8, relative to Day 0, is at least 90%

^cConfidence interval for the difference (Credelio Plus – Nexgard Spectra) in proportions of two independent samples. Non-inferiority is accepted when the lower limit of the interval is greater than − 15