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. 2021 May 16;18:116. doi: 10.1186/s12974-021-02163-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Changes in the percentage fraction of fucosylated and sialylated N-glycans between LPS-injected striatum and contralateral (non-injected (NI)) striatum at seven days post-injection. a Proportion of total N-glycans decorated with either core or outer arm fucose (or both), considering the main glycan structure in each GP. b Percentage fraction of fucosylated N-glycans according to the degree of fucosylation (n = 1, 2, 3, 4), which includes both sialylated and unsialylated fucosylated glycans. Data presented as the mean ± SD, n = 5. Paired Student’s t test was used, and statistically significant difference was set at ****p < 0.0001. c Percentage fraction of sialylated N-glycans according to the degree of sialylation, considering the main glycan structure in each GP. d Percentage fraction of sialylated N-glycans according to the linkage of the sialic acid to galactose residue indicates the significantly high abundance of α(2-3)-linkage to galactose compared to that of α(2-6)-linkage. Data presented as the mean ± SD, n = 5. Paired Student’s t test was used, and statistical significant difference was set at ****p < 0.0001