Fig. 6.

Phenotypic comparisons across variant classes. a Average scores for full scale DQ, nonverbal DQ, and verbal DQ, comparing the two variant types. b Average Vineland-3 standard scores, comparing the two variant types. c Average Vineland-3 v-scale scores, comparing the two variant types. Independent sample t-tests or chi-square analyses were performed to compare the neurobehavioral profiles across variant types. PTV, protein-truncating variant; missense, missense variant or in-frame deletion