Table 1.
Patient characteristics
| Non-ARDS (n = 10) | ARDS (n = 11) | P value | |
|---|---|---|---|
| Age, median (IQR), years | 57 (30–72) | 69 (64–76) | 0.2428 |
| Male/female, number | 8/2 | 10/1 | 0.5865 |
| APACHE2 score, median (IQR) | 7 (4.75–9.75) | 10 (9.00–14.00) | *0.0204 |
| P/F ratio at admission, median (IQR) | 395 (304–454) | 155 (108–203) | *< 0.0001 |
| Mechanical ventilation use, number | 0 | 11 | *< 0.0001 |
| Laboratory data on admission, median (IQR) | |||
| WBC count, cells/μL | 4600 (2525–7925) | 7000 (5800–9600) | 0.1567 |
| Neutrophil count, cells/μL | 2258 (1268–5416) | 5628 (4292–7350) | *0.0430 |
| Lymphocyte count, cells/μL | 1003 (674–1475) | 643 (342–788) | *0.0048 |
| Platelet count, ×103 cells/μL | 186 (86–317) | 220 (176–287) | 0.4262 |
| D-dimer, μg/mL | 0.67 (0.00–1.04) | 1.35 (0.65–2.52) | *0.0404 |
| CRP, mg/dL | 0.98 (0.28–2.06) | 14.62 (9.09–16.89) | *< 0.0001 |
| Creatinine, mg/dL | 0.75 (0.63–0.87) | 0.75 (0.59–0.89) | > 0.9999 |
| Total bilirubin, mg/dL | 0.55 (0.40–0.78) | 0.60 (0.50–1.00) | 0.5661 |
| Alveolar tissue injury marker levels on admission, median (IQR) | |||
| sRAGE, pg/mL | 896 (402–1718) | 2328 (1404–4982) | *0.0079 |
| ANG-2, pg/mL | 334 (65–781) | 699 (405–2201) | 0.1321 |
| SP-D, pg/mL | 2407 (772–3833) | 16,596 (6733–21,397) | *0.0062 |
ARDS acute respiratory distress syndrome, ANG-2 angiopoietin-2, SP-D surfactant protein D, sRAGE soluble form of receptor for advanced glycation end-products, WBC while blood cell, CRP c-reactive protein, IQR interquartile range