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. Author manuscript; available in PMC: 2021 May 17.
Published in final edited form as: Biochem Pharmacol. 2020 Mar 3;175:113896. doi: 10.1016/j.bcp.2020.113896

Figure 5. Inhibition of cytoprotective autophagy shifts the temporal response to cisplatin in the H460crp53 cells.

Figure 5.

A-C. Influence of autophagy inhibition on cisplatin sensitivity in p53 wt and p53 KO cells. Cell viability data from figure 3D and 3E were overlaid to compare the functional role of autophagy in H460crp53 and H460wt cells using the pharmacological inhibitors, CQ (A) and 3MA (B). C. Cell viability data from figure 4D were overlaid to compare the functional role of autophagy on cisplatin sensitivity via genetic silencing of ATG5. p < 0.05: wtp53 shControl + cis vs crp53 shATG5 +cis. ns: wtp53 + cis vs crp53 + cis +CQ (or + 3-MA or shATG5)