Table 6.
Exploratory multivariable analysis of factors associated with contralateral prophylactic mastectomy (CPM)
| Odds Ratio | 95% Confidence Interval | p value | |
|---|---|---|---|
| Family history of breast cancer | |||
| None | Reference | - | - |
| ≥1 2nd degree relative | 1.12 | 0.74 – 1.70 | 0.584 |
| 1 1st degree relative | 1.63 | 1.17 – 2.29 | 0.004 |
| ≥2 1st degree relative | 2.15 | 1.20 – 3.86 | 0.10 |
| Any family history of ovarian cancer | 0.95 | 0.63 – 1.43 | 0.812 |
| Genetic testing | |||
| Not tested | Reference | - | - |
| Positive test | 2.11 | 1.17-3.82 | 0.013 |
| Negative test | 1.55 | 1.10-2.18 | 0.011 |
| Highest level of education | |||
| Less than college | Reference | - | - |
| College | 0.53 | 0.36 – 0.78 | 0.001 |
| More than college | 0.70 | 0.49 – 0.99 | 0.045 |
| White race | 3.57 | 1.23 – 10.36 | 0.019 |
| Younger agea | 1.05 | 0.036 – 0.066 | <0.001 |
a
Age was included in the model as a continuous variable. Odds ratio represents higher odds of contralateral prophylactic mastectomy for those of younger age at diagnosis.