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. Author manuscript; available in PMC: 2021 Nov 15.
Published in final edited form as: Clin Cancer Res. 2021 Mar 8;27(10):2920–2927. doi: 10.1158/1078-0432.CCR-20-4650

Figure 1: Exon 20 insertions.

Figure 1:

15 distinct EGFR ex20ins were identified. The locations and number of each insertion are identified, along with amino acids 761D to 766M, which comprise the regulatory C-helix. Only one insertion (A763_Y764insFQEA) was found in the C-helix; this alteration is predicted to be sensitizing to EGFR TKIs. Amino acids 767A to 775C compose the loop following the C-helix (far loop alterations) where the majority of EGFR ex20ins events occur. Duplication events are labeled in orange and other insertion events are in gray.