Table 1: Patient characteristics:
Basic demographic information was compared between the 106 patients with EGFR ex20ins and all other patients with non-small cell lung cancer (NSCLC) who underwent genomic profiling with MSK-IMPACT. Py indicates pack-years of smoking history. “Other” histologies include carcinoid, sarcomatoid, adenosquamous, lymphoepithelial, and basaloid, among other rare histologies.
|
EGFR ex20ins n=106 n (%) |
NSCLC without EGFR ex20ins n=6,184 n (%) |
||
|---|---|---|---|
| Age, median (range) | 66 (30,−90) | 69 (13, 90) | p<0.001 |
| Sex | p=0.03 | ||
| Male | 33 (31) | 2586 (42) | |
| Female | 73 (69) | 3585 (58) | |
| Not stated | 0 (0) | 13 (<1) | |
| Race | |||
| White | 61 (62) | 4875 (84) | p<0.001 |
| Asian | 22 (22) | 583 (10) | p<0.001 |
| Black | 14 (14) | 318 (6) | p=0.001 |
| Native American | 0 (0) | 9 (<1) | |
| Hawaiian/Pacific Islander | 1 (1) | 5 (<1) | |
| Not known | 8 (8) | 394 (6) | |
| Histology | p<0.001 | ||
| Adenocarcinoma | 102 (96) | 4735 (76) | |
| Squamous | 0 (0) | 655 (11) | |
| Large cell/neuroendocrine | 0 | 142 (2) | |
| Poorly differentiated | 4 (4) | 387 (6) | |
| Other | 0 (0) | 277 (4) | |
| Smoking history | n=985 | p<0.001 | |
| Never smoker | 63 (59) | 314 (32) | |
| ≤15 py | 31 (29) | 192 (20) | |
| >15 py | 12 (11) | 468 (48) | |
| Not known | 0 | 11 (1) | |