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. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: Nat Med. 2021 Apr 1;27(5):785–789. doi: 10.1038/s41591-021-01297-7

Extended Data Fig. 8. Quantification of the photoreceptor sublaminae for 15 months following treatment.

Extended Data Fig. 8

a, Representative OCT scan showing the foveal longitudinal reflectivity profile (LRP) and the three thickness parameters (ONL thickness, IS length, and OS length) and one intensity parameter (IS/OS intensity) quantified. b-e, Photoreceptor sublaminae parameters consisting of outer nuclear layer (ONL) thickness (b), inner segment (IS) length (c), outer segment (OS) length (d), and IS/OS intensity (e) are shown. Seven panels on each row represent data from 7 retinal locations as a function of time after treatment. Gray and black lines delimit test-retest variability in the untreated and treated eye, respectively. Black arrows point to transient changes in IS length and IS/OS intensity between months 2 and 5 in the treated eye (black up triangle). T, temporal retina; N, nasal retina. Each symbol in panels b-e represents the average of three replicates. Interocular differences of the IS/OS intensity at fovea and 1° T and N eccentricities shown in panel e are plotted in Fig.1d.